Cs 527

Counting Carmichael numbers with small seeds

Let As be the product of the first s primes, let Ps be the set of primes p for which p−1 divides As but p does not divide As, and let Cs be the set of Carmichael numbers n such that n is composed entirely of the primes in Ps and such that As divides n − 1. Erdős argued that, for any ε > 0 and all sufficiently large x (depending on the choice of ε), the set Cs contains more than x1−ε Carmichael ...

Antibiotic Treatment and Length of Hospital Stay in Relation to Delivery Mode and Prematurity

AIM To investigate how 1) maternal delivery mode and 2) prematurity in infants are associated to antibiotic treatment and length of hospital stay. METHODS Women having given birth and infants 0-12 months discharged from hospital between July 2005 and November 2011 were identified from the Swedish National Patient Register. Medical records were reviewed for 203 women and 527 infants. The risk ...

A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical probe that modulates SIRT1-associated biological processes. However, the effect of EX-527 on neur...

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has been suggested to modulate p53-dependent functions including DNA damage-induced cell death. In this report, we used EX-527, a novel, potent, and specific small-molecule inhibitor of SIRT1 catalytic activity to examine the role of SIRT1 in p53 acetylation and cell survival after DNA damage. Treatment with EX-527 ...

Equianalgesia: applying evidence-based practice guidelines.